Neostigmine, pyridostigmine and edrophonium as antagonists of deep pancuronium blockade
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چکیده
منابع مشابه
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium.
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium has been studied using the tetanic (50 Hz) and train-of-four (2 Hz) or single twitch responses of the adductor pollicis muscle in 22 anaesthetized patients. A further nine patients not given an anticholinesterase acted as a control group. In two groups (six patients for each anticholinesterase) in whom antagon...
متن کاملNeostigmine and edrophonium antagonism of moderate neuromuscular block induced by pancuronium or tubocurarine.
Edrophonium and neostigmine are anticholinesterase drugs used commonly to antagonize competitive neuromuscular block. Although it has a faster onset of action than neostigmine, edrophonium is unreliable when used to antagonize deep neuromuscular block. We have compared the antagonist characteristics of these two drugs when used to antagonize a moderate degree of pancuronium- or tubocurarine-ind...
متن کاملAntagonism of pancuronium- and pipecuronium-induced neuromuscular block.
We have compared the antagonism of neuromuscular block produced by pipecuronium with pancuronium in 80 anaesthetized surgical patients using mechanomyography and electromyography. Pancuronium 0.1 mg kg-1 or pipecuronium 0.07 mg kg-1 was given after induction of anaesthesia and neuromuscular block was adjusted to 75% twitch depression at the time of antagonism. The following regimens were used: ...
متن کاملRecovery characteristics following antagonism of vecuronium with edrophonium, neostigmine or pyridostigmine.
Vecuronium-induced neuromuscular blocks in 42 ASA physical status I and II females were antagonized with atropine and equipotent doses of edrophonium, neostigmine and pyridostigmine. Recovery characteristics including speed of reversal, dysrhythmias and mean arterial pressure changes were studied. Edrophonium was associated with the fastest neuromuscular recovery. No clinically significant card...
متن کاملSugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine.
BACKGROUND Sugammadex is a modified [gamma] cyclodextrin compound, which encapsulates rocuronium to provide for a rapid reversal of residual neuromuscular blockade. We tested the hypothesis that sugammadex would provide for a more rapid reversal of a moderately profound residual rocuronium-induced blockade than the commonly used cholinesterase inhibitors, edrophonium and neostigmine. METHODS ...
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ژورنال
عنوان ژورنال: Canadian Journal of Anaesthesia
سال: 1987
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03010517